By the time the main PACE trial results were published, the UK had included CBT and GET in clinical guidance for four years - the PACE trial was expected to confirm that they were effective.
The PACE trial has been highly influential in clinical guidelines in the UK, and other countries, in both government funded health care and private medical insurance, and had a significant influence on the Cochrane reviews for ME/CFS treatments.
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The full PACE data led to over 40 scientists writing an open letter to the Lancet to raise serious concerns about the study, and asking for a new, independent analysis of results. Some patients campaigned for the full release of the PACE study's results, and after a five year battle, the PACE trial data was released for others to analyse. This claim has been controversial, however, due to patient groups finding that exercise made patients deteriorate and CBT lacked benefit, and concerns regarding the methodology and refusal to release the full data. The researchers that conducted the trial expected that the CBT and GET groups would see the greatest improvement, and this finding was reported in subsequent articles published by them. The PACE trial compared standardised specialist medical care (SMC) alone to SMC plus Adaptive Pacing Therapy (APT), Cognitive Behavioral Therapy ( CBT), or Graded Exercise Therapy ( GET). The PACE Trial study (short for " Pacing, graded Activity, and Cognitive behaviour therapy a randomised Evaluation") was a large and controversial trial of treatments for people with Chronic Fatigue Syndrome ( CFS), also known as Myalgic Encephalomyelitis (ME).
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